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Issue 23, 2019
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Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

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Abstract

A set of metal–organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells––including those resistant to cisplatin––and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal–organic knots as a new field of chemical space for pharmaceutical design and development.

Graphical abstract: Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

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Publication details

The article was received on 12 Mar 2019, accepted on 26 Apr 2019 and first published on 22 May 2019


Article type: Edge Article
DOI: 10.1039/C9SC01218D
Chem. Sci., 2019,10, 5884-5892
  • Open access: Creative Commons BY-NC license
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    Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

    F. Benyettou, T. Prakasam, A. Ramdas Nair, I. Witzel, M. Alhashimi, T. Skorjanc, J. Olsen, K. C. Sadler and A. Trabolsi, Chem. Sci., 2019, 10, 5884
    DOI: 10.1039/C9SC01218D

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