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Cyclometalated Iridium-BODIPY Ratiometric O2 Sensors

Abstract

Here we introduce a new class of ratiometric O2 sensors for hypoxic environments. Two-component structures composed of phosphorescent cyclometalated Ir(III) complexes and the well-known organic fluorophore BODIPY have been prepared by the 1:1 reaction of bis-cyclometalated iridium synthons with pyridyl-substituted BODIPY compounds. Two different cyclometalating ligands are used, which determine the relative energies of the iridium-centered and BODIPY-centered excited states, and the nature of the linker between iridium and BODIPY also has a small influence on the photoluminescence. Some of the conjugates exhibit dual emission, with significant phosphorescence from the iridium site and fluorescence from the BODIPY, and thus function as ratiometric oxygen sensors. Oxygen quenching experiments demonstrate that as O2 is added the phosphorescence is quenched while the fluorescence is unaffected, with dynamic ranges that are well suited for hypoxic sensing (pO2 < 160 mmHg).

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Publication details

The article was received on 08 Feb 2019, accepted on 12 Apr 2019 and first published on 15 Apr 2019


Article type: Edge Article
DOI: 10.1039/C9SC00696F
Citation: Chem. Sci., 2019, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Cyclometalated Iridium-BODIPY Ratiometric O2 Sensors

    K. S. Choung, K. Marroquin and T. S. Teets, Chem. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9SC00696F

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