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Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

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Abstract

Identifying probiotics and pathogens is of great interest to the health of the human body. It is critical to develop microbiota-targeted therapies to have high specificity including strain specificity. In this study, we have utilized E. coli MG1655 bacteria as living templates to synthesize glycopolymers in situ with high selectivity. By this bacteria-sugar monomer-aptation-polymerization (BS-MAP) method, we have obtained glycopolymers from the surface of bacteria which can recognize template bacteria from two strains of E. coli and the specific bacteria-binding ability of glycopolymers was confirmed by both bacterial aggregation experiment and QCM-D measurements. Furthermore, the synthesized glycopolymers have shown a powerful inhibitory ability which can prevent bacteria from harming cells in both anti-infection and co-culture tests.

Graphical abstract: Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

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Publication details

The article was received on 13 Dec 2018, accepted on 15 Apr 2019 and first published on 18 Apr 2019


Article type: Edge Article
DOI: 10.1039/C8SC05561K
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

    Y. Luo, Y. Gu, R. Feng, J. Brash, Ahmed M. Eissa, D. M. Haddleton, G. Chen and H. Chen, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C8SC05561K

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