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Issue 11, 2019
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Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

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Abstract

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.

Graphical abstract: Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

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Article information


Submitted
15 Nov 2018
Accepted
28 Jan 2019
First published
29 Jan 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 3237-3241
Article type
Edge Article

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

J. B. I. Sap, T. C. Wilson, C. W. Kee, N. J. W. Straathof, C. W. A. Ende, P. Mukherjee, L. Zhang, C. Genicot and V. Gouverneur, Chem. Sci., 2019, 10, 3237 DOI: 10.1039/C8SC05096A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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