Jump to main content
Jump to site search


Hollow Nanoreactors for Pd-catalyzed Suzuki- Miyaura Couplings and O-Propargyl Cleavage Reactions in Bio-relevant Aqueous Media

Abstract

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles, and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-couplings, in water, and under physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in presence of relatively high concentrations of biomolecular components, and even in the presence of mammalian cells.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Oct 2018, accepted on 25 Dec 2018 and first published on 26 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC04390F
Citation: Chem. Sci., 2019, Accepted Manuscript
  • Open access: Creative Commons BY license
  •   Request permissions

    Hollow Nanoreactors for Pd-catalyzed Suzuki- Miyaura Couplings and O-Propargyl Cleavage Reactions in Bio-relevant Aqueous Media

    P. Destito, A. Sousa-Castillo, J. R. Couceiro, F. López, M. A. Correa-Duarte and J. L. Mascareñas, Chem. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C8SC04390F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements