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Issue 9, 2019
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Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

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Abstract

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells.

Graphical abstract: Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

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Publication details

The article was received on 03 Oct 2018, accepted on 25 Dec 2018 and first published on 26 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC04390F
Chem. Sci., 2019,10, 2598-2603
  • Open access: Creative Commons BY license
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    Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

    P. Destito, A. Sousa-Castillo, J. R. Couceiro, F. López, M. A. Correa-Duarte and J. L. Mascareñas, Chem. Sci., 2019, 10, 2598
    DOI: 10.1039/C8SC04390F

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