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Issue 8, 2019
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Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles

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Abstract

We report the co-assembly of aromatic carbohydrate and dipeptide amphiphiles under physiological conditions as a strategy to generate minimalistic proteoglycan mimics. The resulting nanofibers present a structural, fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) core and a functional carbohydrate (Fmoc-glucosamine-6-sulfate or -phosphate) shell. The size, degree of bundling and mechanical properties of the assembled structures depend on the chemical nature of the carbohydrate amphiphile used. In cell culture medium, these nanofibers can further organize into supramolecular hydrogels. We demonstrate that, similar to proteoglycans, the assembled gels prolong the stability of growth factors and preserve the viability of cultured cells. Our results demonstrate that this approach can be applied to the design of extracellular matrix (ECM) substitutes for future regenerative therapies.

Graphical abstract: Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles

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Publication details

The article was received on 01 Oct 2018, accepted on 21 Dec 2018 and first published on 21 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC04361B
Citation: Chem. Sci., 2019,10, 2385-2390
  • Open access: Creative Commons BY-NC license
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    Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles

    A. Brito, Y. M. Abul-Haija, D. S. da Costa, R. Novoa-Carballal, R. L. Reis, R. V. Ulijn, R. A. Pires and I. Pashkuleva, Chem. Sci., 2019, 10, 2385
    DOI: 10.1039/C8SC04361B

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