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Issue 56, 2019
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A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

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Abstract

A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring. Testing against a panel of human tumour cell lines including cervical (A431), ovarian (2008), and colon carcinomas (HCT-15 and LoVo), and two oxaliplatin-resistant clones (LoVo OXP and LoVo MDR) has shown that the new compounds have, in general, equal if not better cytotoxic activity and are able to overcome the oxaliplatin-resistance. Moreover, the oxalato derivative induced lipid droplets increase in LoVo OXP cells thus suggesting the involvement of metabolism stress in its mechanism of action.

Graphical abstract: A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

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Publication details

The article was received on 24 Sep 2019, accepted on 30 Sep 2019 and first published on 11 Oct 2019


Article type: Paper
DOI: 10.1039/C9RA07760J
RSC Adv., 2019,9, 32448-32452
  • Open access: Creative Commons BY-NC license
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    A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

    P. Papadia, V. Gandin, A. Barbanente, A. G. Ruello, C. Marzano, K. Micoli, J. D. Hoeschele, G. Natile and N. Margiotta, RSC Adv., 2019, 9, 32448
    DOI: 10.1039/C9RA07760J

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