Formal synthesis of (+)-lactacystin from l-serine†
Abstract
A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
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* Corresponding authors
a
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK
E-mail:
p.page@uea.ac.uk
b School of Chemistry, University of St Andrews, St Andrews, Scotland KY16 9ST, UK
c School of Science & Technology, Nottingham Trent University, Clifton, Nottingham NG11 8NS, UK
A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
P. C. Bulman Page, R. L. Goodyear, Y. Chan, A. M. Z. Slawin and S. M. Allin, RSC Adv., 2019, 9, 30019 DOI: 10.1039/C9RA07244F
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