Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging

Abstract

In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r₁ value and the r₂/r₁ ratio were about 5.6 mM⁻¹ s⁻¹ and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.