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Issue 49, 2019
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A study on graphene composites for peripheral nerve injury repair under electrical stimulation

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Abstract

Electrical stimulation (ES) provides an effective alternative to peripheral nerve repair via conductive scaffolds. The aim of the present study is to investigate a graphene (GR)/thermoplastic polyurethane (TPU) composite for the repair of peripheral nerve injury under ES. To this end, conductive composite membranes were fabricated by blending GR (2, 4 and 6 wt%) with TPU. GR maintains its own structure in the composite and enhances the mechanical and electrical properties of the composite. The composites with excellent biocompatibility had a hemolysis rate of less than 5%. As a result, the 4GR–TPU (4 wt% GR) sample with enhanced mechanical properties possessed the highest conductivity value of 33.45 ± 0.78 S m−1. Compared with the non-conductive sample, 4GR–TPU was favorable for the viability of Schwann cells (SCs) under ES. When different voltages of ES were applied, a direct current of 10 mV was more suitable for the growth and proliferation of SCs. This study provides beneficial information for peripheral nerve repair via ES.

Graphical abstract: A study on graphene composites for peripheral nerve injury repair under electrical stimulation

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Publication details

The article was received on 27 Jun 2019, accepted on 21 Aug 2019 and first published on 11 Sep 2019


Article type: Paper
DOI: 10.1039/C9RA04855C
RSC Adv., 2019,9, 28627-28635
  • Open access: Creative Commons BY-NC license
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    A study on graphene composites for peripheral nerve injury repair under electrical stimulation

    Z. Huang, Z. Guo, M. Sun, S. Fang and H. Li, RSC Adv., 2019, 9, 28627
    DOI: 10.1039/C9RA04855C

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