Issue 46, 2019

15N labeling and analysis of 13C–15N and 1H–15N couplings in studies of the structures and chemical transformations of nitrogen heterocycles

Abstract

This review provides a generalization of effective examples of 15N labeling followed by an analysis of 13C–15N (JCN) and 1H–15N (JHN) coupling constants in solution as a tool to study the structural aspects and pathways of chemical transformations (e.g., rearrangements and ring-chain tautomerisms) in monocyclic and fused nitrogen heterocycles. This approach allows us to significantly expand and supplement the scope of NMR techniques for heterocyclic compounds. Moreover, methods for the incorporation of 15N atoms into the cores of various N-heterocycles have been collected in this work.

Graphical abstract: 15N labeling and analysis of 13C–15N and 1H–15N couplings in studies of the structures and chemical transformations of nitrogen heterocycles

Article information

Article type
Review Article
Submitted
26 Jun 2019
Accepted
19 Aug 2019
First published
28 Aug 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 26856-26879

15 N labeling and analysis of 13C–15N and 1H–15N couplings in studies of the structures and chemical transformations of nitrogen heterocycles

S. L. Deev, I. A. Khalymbadzha, T. S. Shestakova, V. N. Charushin and O. N. Chupakhin, RSC Adv., 2019, 9, 26856 DOI: 10.1039/C9RA04825A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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