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Issue 34, 2019
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Next-generation of selective histone deacetylase inhibitors

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Abstract

Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of cancers. First-generation inhibitors are mainly pan-HDACis that target multiple isoforms which might lead to serious side effects. At present, the next-generation HDACis are mainly focused on being class- or isoform-selective which can provide improved risk–benefit profiles compared to non-selective inhibitors. Because of the rapid development in next-generation HDACis, it is necessary to have an updated and state-of-the-art overview. Here, we summarize the strategies and achievements of the selective HDACis.

Graphical abstract: Next-generation of selective histone deacetylase inhibitors

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Article information


Submitted
22 Apr 2019
Accepted
17 Jun 2019
First published
24 Jun 2019

This article is Open Access

RSC Adv., 2019,9, 19571-19583
Article type
Review Article

Next-generation of selective histone deacetylase inhibitors

F. Yang, N. Zhao, D. Ge and Y. Chen, RSC Adv., 2019, 9, 19571
DOI: 10.1039/C9RA02985K

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