Issue 19, 2019, Issue in Progress

Alleviating concentration polarization: a micro three-electrode interdigitated glucose sensor based on nanoporous gold from a mild process

Abstract

Precisely detecting the concentration of glucose in the human body is an attractive way to prevent or diagnose diabetes. Compared with the traditional enzyme-based electrochemical glucose sensors, the non-enzymatic ones have gradually come to people's attention recently. By integrating three electrodes into one device, glucose sensors can achieve superior performance and are convenient to carry. Herein, a non-enzymatic three-electrode interdigitated glucose sensor (TEIDGS) based on nanoporous gold is designed and fabricated. To our best knowledge, it is the first time that interdigitated electrodes are combined in a single non-enzymatic glucose sensor device. Due to the advantage of the interdigitated structure and the smart design of the three-electrode circuit board, the TEIDGS can effectively reduce concentration polarization and achieve a high detective sensitivity for glucose of 1217 μA mM−1 cm−2 and 343 μA mM−1 cm−2 in the ranges of 0.001–0.590 mM and 0.59–7.00 mM, respectively. Moreover, a low detection limit of 390 nM can be reached. In addition, this TEIDGS possesses excellent selectivity for glucose among other interferents. Strikingly, after three weeks of operation, it can still retain a high detection performance. This work will certainly provide an efficient structure and proper catalytic material choice for future non-enzymatic glucose sensors.

Graphical abstract: Alleviating concentration polarization: a micro three-electrode interdigitated glucose sensor based on nanoporous gold from a mild process

Supplementary files

Article information

Article type
Paper
Submitted
21 Dec 2018
Accepted
07 Mar 2019
First published
03 Apr 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 10465-10472

Alleviating concentration polarization: a micro three-electrode interdigitated glucose sensor based on nanoporous gold from a mild process

G. Fan, P. Sun, J. Zhao, D. Han, L. Niu and G. Cui, RSC Adv., 2019, 9, 10465 DOI: 10.1039/C8RA10459J

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