Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines†
Sergey A.
Rzhevskiy, 
ab
Alexandra A.
Ageshina,
a
Gleb A.
Chesnokov,
ab
Pavel S.
Gribanov,
ac
Maxim A.
Topchiy,
ab
Mikhail S.
Nechaev
*ab
and
Andrey F.
Asachenko
*ab
ab
Alexandra A.
Ageshina,
a
Gleb A.
Chesnokov,
ab
Pavel S.
Gribanov,
ac
Maxim A.
Topchiy,
ab
Mikhail S.
Nechaev
*ab
and
Andrey F.
Asachenko
*ab
Abstract
A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.
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