Issue 1, 2019, Issue in Progress
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RSC Advances

Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group†

Yuya Goto,a   Masafumi Ueda,ab   Kouta Sugikawa, ORCID logo a   Kazuma Yasuharac  and  Atsushi Ikeda ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan

b School of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan

c Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan

Abstract

The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm.

Graphical abstract: Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group

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Article information

DOI
https://doi.org/10.1039/C8RA08584F
Article type
Paper
Submitted
17 Oct 2018
Accepted
11 Dec 2018
First published
21 Dec 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 166-171

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Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group

Y. Goto, M. Ueda, K. Sugikawa, K. Yasuhara and A. Ikeda, RSC Adv., 2019, 9, 166 DOI: 10.1039/C8RA08584F

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