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PhI(OAc)2-mediated oxidative rearrangement of allylic amides: efficient synthesis of oxazoles and β-keto amides

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Abstract

A series of 2,5-disubstituted oxazoles and β-keto amides were synthesized from allylic amides via PhI(OAc)2-mediated intramolecular cyclization and oxidation with the migration of an aryl group. These reactions were performed under mild conditions with good functional group tolerance and gave the corresponding products in good to excellent yields.

Graphical abstract: PhI(OAc)2-mediated oxidative rearrangement of allylic amides: efficient synthesis of oxazoles and β-keto amides

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Publication details

The article was received on 24 Oct 2019, accepted on 14 Nov 2019 and first published on 15 Nov 2019


Article type: Research Article
DOI: 10.1039/C9QO01298B
Org. Chem. Front., 2020, Advance Article

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    PhI(OAc)2-mediated oxidative rearrangement of allylic amides: efficient synthesis of oxazoles and β-keto amides

    K. Xu, S. Yang and Z. Ding, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01298B

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