Issue 22, 2019

Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

Abstract

A highly efficient Pd-catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates was developed. This method provided an efficient and simple strategy for the synthesis of tetrasubstituted imidazolone derivatives in good to excellent yields via sulfonyl guanidine intermediates. This protocol shows a broad substrate scope and mild reaction conditions, and new C–C, and C–N bonds were constructed via a three-component reaction in one step.

Graphical abstract: Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
10 Sep 2019
Accepted
27 Sep 2019
First published
30 Sep 2019

Org. Chem. Front., 2019,6, 3754-3758

Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

F. Wang, P. Xu, B. Liu, S. Wang and S. Ji, Org. Chem. Front., 2019, 6, 3754 DOI: 10.1039/C9QO01122F

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