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Issue 21, 2019
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Ring-opening/annulation reaction of cyclopropyl ethanols: concise access to thiophene aldehydes via C–S bond formation

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Abstract

The synthesis of thiophene aldehydes from easily available cyclopropyl ethanol derivatives and potassium sulfide has been developed. This novel one-pot procedure achieves double C–S bond formation via the cleavage of C–C bonds. This transformation shows good functional group tolerance under mild reaction conditions. Moreover, DMSO acts as the solvent and mild oxidant simultaneously in this reaction.

Graphical abstract: Ring-opening/annulation reaction of cyclopropyl ethanols: concise access to thiophene aldehydes via C–S bond formation

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Article information


Submitted
13 Aug 2019
Accepted
30 Sep 2019
First published
01 Oct 2019

Org. Chem. Front., 2019,6, 3705-3709
Article type
Research Article

Ring-opening/annulation reaction of cyclopropyl ethanols: concise access to thiophene aldehydes via C–S bond formation

T. Wang, Z. An, Z. Qi, D. Zhuang, A. Chang, Y. Yang and R. Yan, Org. Chem. Front., 2019, 6, 3705
DOI: 10.1039/C9QO01014A

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