Jump to main content
Jump to site search

Issue 16, 2019
Previous Article Next Article

Thiol substrate-promoted dehydrogenative cyclization of arylmethyl thiols with ortho-substituted amines: a universal approach to heteroaromatic compounds

Author affiliations

Abstract

A thiol substrate-promoted one-pot synthesis of a library of heteroaromatic compounds was developed. Benzo[d]oxazole, benzo[d]thiazole, benzo[d]imidazole, oxazolo[4,5-b]pyridine and naphtho[2,3-d]oxazole derivatives were obtained under metal-free and external oxidant-free conditions in moderate to excellent yields. Commercially available substrates and the absence of supplemental catalysts, oxidants or additives make this method both practical and efficient.

Graphical abstract: Thiol substrate-promoted dehydrogenative cyclization of arylmethyl thiols with ortho-substituted amines: a universal approach to heteroaromatic compounds

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Apr 2019, accepted on 13 Jun 2019 and first published on 15 Jun 2019


Article type: Research Article
DOI: 10.1039/C9QO00554D
Org. Chem. Front., 2019,6, 2844-2849

  •   Request permissions

    Thiol substrate-promoted dehydrogenative cyclization of arylmethyl thiols with ortho-substituted amines: a universal approach to heteroaromatic compounds

    J. Zhang, M. Qiao, L. Chen, Y. Dong, C. Jiao, S. Liao and Y. Wu, Org. Chem. Front., 2019, 6, 2844
    DOI: 10.1039/C9QO00554D

Search articles by author

Spotlight

Advertisements