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Issue 12, 2019
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Bimolecular oxidative C–H alkynylation of α-substituted isochromans

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Abstract

A bimolecular oxidative C–H functionalization of secondary benzylic ethers for new C–C bond formation has been established. A wide range of α-substituted isochromans underwent oxidative C–H alkynylation with diverse potassium trifluoroborates, affording respective oxygen heterocycles bearing α-tetrasubstituted stereocenters in high efficiency.

Graphical abstract: Bimolecular oxidative C–H alkynylation of α-substituted isochromans

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Article information


Submitted
11 Mar 2019
Accepted
18 Apr 2019
First published
20 Apr 2019

Org. Chem. Front., 2019,6, 2028-2031
Article type
Research Article

Bimolecular oxidative C–H alkynylation of α-substituted isochromans

Y. Mao, M. Cao, X. Pan, J. Huang, J. Li, L. Xu and L. Liu, Org. Chem. Front., 2019, 6, 2028
DOI: 10.1039/C9QO00352E

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