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Issue 10, 2019
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Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

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Abstract

Five novel formyl-phloroglucinol-β-caryophyllene meroterpenoids, namely littordials A–E (1–5), were isolated from the leaves of Psidium littorale. Their structures were established by spectroscopic data and computational methods, and the structure of 1 was confirmed by X-ray crystallography. Littordials A–E feature unusual acyl phloroglucinol units, and 5 possesses a rare 6/7/9/4-fused tetracyclic ring system. Compounds 2, 3 and 5 exhibited cytotoxic activities on two cancer cell lines (MDA-MB-231 and B16) with IC50 values from 6.6 ± 1.5 to 9.2 ± 1.7 μM.

Graphical abstract: Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

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Publication details

The article was received on 02 Feb 2019, accepted on 25 Mar 2019 and first published on 26 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00174C
Org. Chem. Front., 2019,6, 1667-1673

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    Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

    J. Xu, H. Zhu, J. Zhang, W. Liu, J. Luo, K. Pan, W. Cao, Q. Bi, F. Feng and W. Qu, Org. Chem. Front., 2019, 6, 1667
    DOI: 10.1039/C9QO00174C

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