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A L-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

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Abstract

We report herein a L-glutamate (L-Glu)-responsive delivery system. It consists of Janus Au–mesoporous silica (MS) nanoparticles functionalized with L-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of L-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of L-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.

Graphical abstract: A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

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Publication details

The article was received on 21 Jan 2019, accepted on 11 Mar 2019 and first published on 12 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00093C
Citation: Org. Chem. Front., 2019, Advance Article

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    A L-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

    T. M. Godoy-Reyes, A. Llopis-Lorente, A. García-Fernández, P. Gaviña, A. M. Costero, R. Villalonga, F. Sancenón and R. Martínez-Máñez, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00093C

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