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Issue 8, 2019
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Ruthenium(ii)-catalyzed selective C–H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles

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Abstract

Ruthenium-catalyzed selective C–H bond activation of imidamides and annulation of sulfoxonium ylides were achieved, which afforded a series of 3-ketoindole derivatives in good yields, with good functional group compatibility. The catalytic system generated an indole scaffold by C–N and C–S bond cleavage. This reaction constitutes the first intermolecular coupling of ylides with arenes to afford a 3-ketoindole skeleton by ruthenium-catalyzed C–H activation and annulation cascade.

Graphical abstract: Ruthenium(ii)-catalyzed selective C–H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles

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Article information


Submitted
11 Jan 2019
Accepted
26 Feb 2019
First published
27 Feb 2019

Org. Chem. Front., 2019,6, 1183-1188
Article type
Research Article

Ruthenium(II)-catalyzed selective C–H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles

C. Wu, J. Zhou, G. He, H. Li, Q. Yang, R. Wang, Y. Zhou and H. Liu, Org. Chem. Front., 2019, 6, 1183
DOI: 10.1039/C9QO00048H

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