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Nickel-catalyzed regioselective C–H oxygenation: new routes for versatile C–O bond formation

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Abstract

Nickel-catalyzed regioselective C–H oxygenation reactions of chelating arenes using iodobenzene diacetate, alcohols, and benzoic acids respectively as attacking reagents have been developed for the first time. Simplicity of operation, broad range of functional group tolerance, use of cheap transition metal nickel, and avoiding extraneous directing groups are the key features, thus providing an important complement to C–H oxygenation reactions and expanding the field of nickel-catalyzed C–H functionalizations. Explorations of mechanistic details are also described.

Graphical abstract: Nickel-catalyzed regioselective C–H oxygenation: new routes for versatile C–O bond formation

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Publication details

The article was received on 23 Nov 2018, accepted on 11 Jan 2019 and first published on 15 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01274A
Citation: Org. Chem. Front., 2019, Advance Article

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    Nickel-catalyzed regioselective C–H oxygenation: new routes for versatile C–O bond formation

    Z. Li, K. Sun and C. Cai, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01274A

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