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Issue 8, 2019
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Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

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Abstract

Historically, sulfoximines, sulfondiimines and sulfonimidamides have been neglected pharmacophores in drug discovery even though they offer very interesting properties. This highlight shares the key learnings of various lead optimization approaches at Bayer AG that have successfully utilized these neglected sulfur(VI) functional groups to deliver multiple clinical candidates. In this context, the key synthetic methods utilized for the synthetic preparation of these unusual compounds will be outlined.

Graphical abstract: Neglected sulfur(vi) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

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Publication details

The article was received on 13 Nov 2018, accepted on 13 Dec 2018 and first published on 22 Mar 2019


Article type: Highlight
DOI: 10.1039/C8QO01233D
Org. Chem. Front., 2019,6, 1319-1324
  • Open access: Creative Commons BY-NC license
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    Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

    U. Lücking, Org. Chem. Front., 2019, 6, 1319
    DOI: 10.1039/C8QO01233D

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