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Cu/Pd-catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles

Abstract

A novel and efficient Cu/Pd-catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles has been developed. High selectivity is achieved by the same substrates going though different reaction pathways catalyzed by different metal catalysts. Moreover, this method has broad substrates scope and high efficacy on gram large-scale reaction. Plausible mechanism was proposed on the basis of control experiments.

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Publication details

The article was received on 07 Nov 2018, accepted on 09 Jan 2019 and first published on 10 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01206G
Citation: Org. Chem. Front., 2019, Accepted Manuscript
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    Cu/Pd-catalyzed chemoselective synthesis of C-3 dicarbonyl indoles and bis(indolyl)alkanes from aldehydes and indoles

    S. Guo, Z. Fang, B. Zhou, J. Hua, Z. Dai, Z. Yang, C. Liu, W. He and K. Guo, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C8QO01206G

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