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Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction

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Abstract

An efficient approach to difluoroalkylated pyrrolobenzodiazepines has been developed using a Pd-catalyzed two-component C–H difluoroalkylation/cyclization cascade reaction. This protocol constitutes a straightforward route for the synthesis of difluoroalkylated pyrrolobenzodiazepine derivatives in good yields with excellent functional group tolerance.

Graphical abstract: Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction

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Publication details

The article was received on 25 Oct 2018, accepted on 20 Dec 2018 and first published on 08 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01154K
Citation: Org. Chem. Front., 2019, Advance Article
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    Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction

    Y. Gao, C. Li, B. Xu and H. Liu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01154K

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