Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C–H difluoroalkylation/cyclization cascade reaction†
Abstract
An efficient approach to difluoroalkylated pyrrolobenzodiazepines has been developed using a Pd-catalyzed two-component C–H difluoroalkylation/cyclization cascade reaction. This protocol constitutes a straightforward route for the synthesis of difluoroalkylated pyrrolobenzodiazepine derivatives in good yields with excellent functional group tolerance.