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Issue 41, 2019
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Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation

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Abstract

Poly(acryloyl hydrazide) is a versatile polymer scaffold readily functionalised through post-polymerisation modification with aldehydes to yield polymers for biological applications. However, its polymerisation is affected by nucleophilic degradation of the RAFT agent that leads to early termination, an issue often overlooked in the polymerisation of primary acrylamides. Here we report the effect of temperature on the RAFT polymerisation of N′-(tert-butoxycarbonyl)acryloyl hydrazide (1) and demonstrate that by carefully selecting this polymerisation temperature, a balance between rate of polymerisation and rate of degradation of the RAFT agent can be achieved. This way greater control over the polymerisation process is achieved, allowing the synthesis of Boc-protected poly(acryloyl hydrazide) with higher degrees of polymerisation (DP) than those obtained previously, while still maintaining low dispersities (ĐM).

Graphical abstract: Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation

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Supplementary files

Article information


Submitted
13 Aug 2019
Accepted
02 Oct 2019
First published
03 Oct 2019

This article is Open Access

Polym. Chem., 2019,10, 5645-5651
Article type
Paper

Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation

O. Creese, P. Adoni, G. Su, A. Romanyuk and P. Fernandez-Trillo, Polym. Chem., 2019, 10, 5645
DOI: 10.1039/C9PY01222B

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