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Multi-stimuli Responsive Trigger for Temporally Controlled Depolymerization of Self-immolative Polymers

Abstract

For many decades, stimuli reponsive materials have been studied and utilized in various fields, ranging from chemical sensors to controlled drug release. Among those responsive materials are self-immolative polymers (SIP) that allow for end-to-end depolymerization and the ability to release a desired cargo on demand or amplify analyte detection. However, in typical SIP systems, the triggering event leads to a relatively uncontrolled degradation process. Herein we present a multi-stimuli trigger that utilizes the combination of heat and acid to impart control over the trigger event and thus the degradation process. By controlling this reaction, we achieve temporal control over the trigger cleavage and subsequent depolymerization and release of cargo from the SIP.

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Publication details

The article was received on 24 Feb 2019, accepted on 09 Aug 2019 and first published on 12 Aug 2019


Article type: Communication
DOI: 10.1039/C9PY00301K
Polym. Chem., 2019, Accepted Manuscript

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    Multi-stimuli Responsive Trigger for Temporally Controlled Depolymerization of Self-immolative Polymers

    M. Nichol, K. Clark, N. D. Dolinski and J. Read de Alaniz, Polym. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9PY00301K

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