Issue 12, 2019

Turn-on fluorescence and photodynamic activity of β-(1,3-1,6)-d-glucan-complexed porphyrin derivatives inside HeLa cells

Abstract

Fluorescence intensities of water-soluble β-(1,3-1,6)-D-glucan (β-1,3-glucan)-complexed porphyrin derivatives were very weak as a result of self-quenching. However, β-1,3-glucan-complexed tetra(aminophenyl)porphyrin exhibited ‘off-state’ to ‘on-state’ fluorescence switching activity by intracellular uptake. Furthermore, the internalised complex showed a high level of photodynamic activity toward HeLa cells under photoirradiation at long wavelengths.

Graphical abstract: Turn-on fluorescence and photodynamic activity of β-(1,3-1,6)-d-glucan-complexed porphyrin derivatives inside HeLa cells

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2019
Accepted
12 Nov 2019
First published
12 Nov 2019

Photochem. Photobiol. Sci., 2019,18, 2854-2858

Turn-on fluorescence and photodynamic activity of β-(1,3-1,6)-D-glucan-complexed porphyrin derivatives inside HeLa cells

S. Hino, R. Funada, K. Sugikawa, K. Koumoto, T. Suzuki, T. Nagasaki and A. Ikeda, Photochem. Photobiol. Sci., 2019, 18, 2854 DOI: 10.1039/C9PP00208A

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