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Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

Abstract

A water-soluble pillar[5]arene, decafunctionalized with thioether and carboxylate fragments, was synthesized as a structural analogue of Sugammadex. Its ability to rescue contraction of the diaphragm muscle by encapsulating the muscle relaxant rocuronium bromide was demonstrated. Using UV-vis, NMR and fluorescence spectroscopy, it was shown that the muscle relaxant is associated with the pillar[5]arene with association constant of 4500 M-1 and a stoichiometry of 1:1. The structure of the inclusion complex of the pillar[5]arene with rocuronium bromide was additionally investigatedby quantum chemical methods.

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Publication details

The article was received on 12 Oct 2019, accepted on 07 Nov 2019 and first published on 07 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB02215E
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

    D. Shurpik, O. Mostovaya, D. A. Sevastyanov, O. A. Lenina, S. Anastasia, A. D. Voloshina, K. A. Petrov, I. V. Kovyazina, P. Cragg and I. Stoikov, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB02215E

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