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Intermolecular Scandium Triflate-Promoted Nitrene-Transfer [5+1] Cycloadditions of Vinylcyclopropanes

Abstract

Sc(OTf)3-promoted [5+1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. This represents the second example of a [5+1] nitrene-transfer cycloaddition and exhibits complementary substrate scope to the antecedent work, expanding the range of N-heterocycles accessible via this strategy.

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Publication details

The article was received on 23 Aug 2019, accepted on 09 Oct 2019 and first published on 09 Oct 2019


Article type: Communication
DOI: 10.1039/C9OB01858A
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Intermolecular Scandium Triflate-Promoted Nitrene-Transfer [5+1] Cycloadditions of Vinylcyclopropanes

    J. Laudenschlager, L. A. Combee and M. Hilinski, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01858A

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