Jump to main content
Jump to site search

Issue 37, 2019
Previous Article Next Article

Hyperconjomer stereocontrol of cationic polyene cyclisations

Author affiliations

Abstract

Polyene cyclisations are a powerful method for the direct generation of molecular complexity. This paper describes the use of computational methods to investigate the stereoselectivity of cationic polyene cyclisations of geranylbenzene derivatives. The outcomes highlight the different reactivity of hyperconjomers during the key Friedel–Crafts alkylation step, and informed a successful strategy for the synthesis of (±)-taiwaniaquinone G with improved levels of stereoselectivity.

Graphical abstract: Hyperconjomer stereocontrol of cationic polyene cyclisations

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Jun 2019, accepted on 06 Sep 2019 and first published on 10 Sep 2019


Article type: Paper
DOI: 10.1039/C9OB01364D
Org. Biomol. Chem., 2019,17, 8551-8560

  •   Request permissions

    Hyperconjomer stereocontrol of cationic polyene cyclisations

    R. T. Rodger, M. S. Graham and C. S. P. McErlean, Org. Biomol. Chem., 2019, 17, 8551
    DOI: 10.1039/C9OB01364D

Search articles by author

Spotlight

Advertisements