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Issue 38, 2019
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Application of isatin-derived saturated esters in the synthesis of 3,3′-spirooxindole γ-butyrolactams

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Abstract

Stable while reactive isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3 + 2] annulation with N-Boc imines. The developed protocol offers a direct pathway for the rapid and divergent construction of two classes of 3,3′-spirooxindole γ-butyrolactam skeletons that are recognized as the privileged structures of various bioactive compounds. This protocol also has the advantages of mild reaction conditions, scalability and wide reaction scope.

Graphical abstract: Application of isatin-derived saturated esters in the synthesis of 3,3′-spirooxindole γ-butyrolactams

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Publication details

The article was received on 14 Jun 2019, accepted on 12 Sep 2019 and first published on 12 Sep 2019


Article type: Paper
DOI: 10.1039/C9OB01347D
Org. Biomol. Chem., 2019,17, 8745-8748

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    Application of isatin-derived saturated esters in the synthesis of 3,3′-spirooxindole γ-butyrolactams

    J. Zhu, S. Fang, S. Jin, R. Ma, T. Lu and D. Du, Org. Biomol. Chem., 2019, 17, 8745
    DOI: 10.1039/C9OB01347D

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