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Transition-metal free oxidative C-H etherification of acylanilines with alcohols through a radical pathway

Abstract

A transition metal free approach for the synthesis of methyl/ethyl aryl ether via oxidative C-H etherification of acylanilines with alcohols has been developed. Various acylanilines are compatible under standard conditions, giving the corresponding products in moderate to good yields. This strategy avoids transition-metal catalyst and excessive alcohol, providing a simple and reliable alternative method for the synthesis of methyl/ethyl aryl ether. Control experiments reveal that a radical mechanism is involved in this transformation.

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Publication details

The article was received on 27 May 2019, accepted on 11 Jun 2019 and first published on 12 Jun 2019


Article type: Communication
DOI: 10.1039/C9OB01224A
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Transition-metal free oxidative C-H etherification of acylanilines with alcohols through a radical pathway

    X. Xu, Z. Chu and C. Xia, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01224A

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