Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 28, 2019
Previous Article Next Article

A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

Author affiliations

Abstract

We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX, and replicate the DNA binding of the native protein. The versatility of the reported synthetic approach enabled the straightforward preparation of MYC and Omomyc analogues, as well as fluorescently labeled derivatives.

Graphical abstract: A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

Back to tab navigation

Supplementary files

Article information


Submitted
23 May 2019
Accepted
29 May 2019
First published
29 May 2019

Org. Biomol. Chem., 2019,17, 6748-6752
Article type
Communication

A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

R. Calo-Lapido, C. Penas, A. Jiménez-Balsa, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2019, 17, 6748
DOI: 10.1039/C9OB01209E

Social activity

Search articles by author

Spotlight

Advertisements