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Facile Synthesis of Chiral ε-Sultams via Organocatalytic Aza-Friedel-Crafts Reaction

Abstract

A facile enantioselective aza-Friedel-Crafts reaction of seven-membered cyclic N-sulfonylimines with naphthols was developed with cinchona alkaloid-based bifunctional organocatalyst, giving the chiral ε-sultams with up to 92% ee.

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Publication details

The article was received on 17 May 2019, accepted on 11 Jun 2019 and first published on 12 Jun 2019


Article type: Communication
DOI: 10.1039/C9OB01158G
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Facile Synthesis of Chiral ε-Sultams via Organocatalytic Aza-Friedel-Crafts Reaction

    Z. Zhao, L. shi, Y. Li, F. Meng and Y. Zhou, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01158G

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