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Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions

Abstract

Asymmetric catalysis represents an efficient approach to prepare optically active compounds. Commonly, both enantiomers of a chiral catalyst are used to synthesize two enantiomers of a chiral compound, however, it is quite difficult to obtain the catalysts with opposite configuration in most cases. Thus, chemists pay much attention to looking for new strategies. Enantiodivergent synthesis demonstrates cost effectiveness and practicability to solve this issue by tuning the reaction parameters with use of the ligands derived from a single chiral source. In 2003 and 2008, two reviews have commendably summarized the enantiodivergent reactions, and some representative examples were illustrated. In this view, reversal of enantioselectivity in metal complexes-mediated asymmetric catalysis from 2008 to present was updated. Several factors of delivering enantiodivergence are introduced, including metal salts, ligands, additives, solvents, temperature and so on.

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Publication details

The article was received on 05 May 2019, accepted on 11 Jun 2019 and first published on 12 Jun 2019


Article type: Review Article
DOI: 10.1039/C9OB01027K
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions

    W. Cao, X. Feng and X. Liu, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01027K

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