Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions
Asymmetric catalysis represents an efficient approach to prepare optically active compounds. Commonly, both enantiomers of a chiral catalyst are used to synthesize two enantiomers of a chiral compound, however, it is quite difficult to obtain the catalysts with opposite configuration in most cases. Thus, chemists pay much attention to looking for new strategies. Enantiodivergent synthesis demonstrates cost effectiveness and practicability to solve this issue by tuning the reaction parameters with use of the ligands derived from a single chiral source. In 2003 and 2008, two reviews have commendably summarized the enantiodivergent reactions, and some representative examples were illustrated. In this view, reversal of enantioselectivity in metal complexes-mediated asymmetric catalysis from 2008 to present was updated. Several factors of delivering enantiodivergence are introduced, including metal salts, ligands, additives, solvents, temperature and so on.
- This article is part of the themed collection: Catalysis & biocatalysis in OBC