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Issue 14, 2019
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An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A–D and their derivatives

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Abstract

Oxazoles are an important class of biologically active metabolites from nature, and exhibit broad biological activities as the lead for drug discovery. Hinduchelins are a class of unusual natural products with an oxazole unit, isolated from Streptoalloteichus hindustanus, and with a potential iron-chelating ability. These compounds are the first identified naturally occurring unusual oxazole derivatives to possess a catechol unit. However, some of these compounds are not abundant in nature, and thus, the efficient syntheses of these compounds are advantageous in exploring their potential applications. This paper reports the efficient synthesis and bio-evaluation of hinduchelins A–D and their derivatives with convenient procedures and high yields.

Graphical abstract: An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A–D and their derivatives

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Article information


Submitted
13 Feb 2019
Accepted
20 Mar 2019
First published
21 Mar 2019

Org. Biomol. Chem., 2019,17, 3635-3639
Article type
Paper

An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A–D and their derivatives

S. Ke, Z. Zhang, L. Shi, M. Liu, W. Fang, Y. Zhang, Z. Wu, Z. Wan, T. Long and K. Wang, Org. Biomol. Chem., 2019, 17, 3635
DOI: 10.1039/C9OB00352E

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