Issue 15, 2019

I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides

Abstract

An easy and efficient approach to the synthesis of N,4-disubstituted quinazoline-2-amine and oxides is described. This transformation proceeds smoothly in the presence of molecular iodine. The metal-free protocol presented here is insensitive to air moisture and operationally simple. This versatile and synthetic methodology is broadly applicable to a variety of N,4-disubstituted quinazoline-2-amines and oxides, which are synthesized in good to excellent yields starting from readily available inexpensive precursors.

Graphical abstract: I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2019
Accepted
06 Mar 2019
First published
07 Mar 2019

Org. Biomol. Chem., 2019,17, 3714-3717

I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides

N. Jatangi and R. K. Palakodety, Org. Biomol. Chem., 2019, 17, 3714 DOI: 10.1039/C9OB00349E

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