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Issue 10, 2019
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Total synthesis of levetiracetam

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Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.

Graphical abstract: Total synthesis of levetiracetam

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The article was received on 16 Jan 2019, accepted on 15 Feb 2019 and first published on 15 Feb 2019

Article type: Paper
DOI: 10.1039/C9OB00111E
Org. Biomol. Chem., 2019,17, 2770-2775

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    Total synthesis of levetiracetam

    A. Narczyk, M. Mrozowicz and S. Stecko, Org. Biomol. Chem., 2019, 17, 2770
    DOI: 10.1039/C9OB00111E

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