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Issue 10, 2019
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Total synthesis of levetiracetam

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Abstract

Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.

Graphical abstract: Total synthesis of levetiracetam

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Article information


Submitted
16 Jan 2019
Accepted
15 Feb 2019
First published
15 Feb 2019

Org. Biomol. Chem., 2019,17, 2770-2775
Article type
Paper

Total synthesis of levetiracetam

A. Narczyk, M. Mrozowicz and S. Stecko, Org. Biomol. Chem., 2019, 17, 2770
DOI: 10.1039/C9OB00111E

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