Issue 8, 2019

The roles of Lewis acidic additives in organotransition metal catalysis

Abstract

We describe recent examples of prominent reactions in organic synthesis that involve transition metal and Lewis acid cocatalysts. Introducing Lewis acid additives to transition metal catalysis can enable new reactivity or improve activity and selectivity of an existing process. Several studies are highlighted to illustrate the possible roles of Lewis acids in catalytic mechanisms. The uses of Lewis acid additives in bond-breaking catalysis (C–C activation, C–H activation, and hydrogenolysis reactions) and bond-forming catalysis (Au-catalysed alkyne functionalisation, Pd-catalysed C–C and C–N bond formation) are reviewed.

Graphical abstract: The roles of Lewis acidic additives in organotransition metal catalysis

Article information

Article type
Review Article
Submitted
15 Nov 2018
Accepted
14 Jan 2019
First published
22 Jan 2019
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2019,17, 2055-2069

The roles of Lewis acidic additives in organotransition metal catalysis

J. Becica and G. E. Dobereiner, Org. Biomol. Chem., 2019, 17, 2055 DOI: 10.1039/C8OB02856G

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