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Visible-light induced decarboxylative C2-alkylation of benzothiazoles with carboxylic acids under metal-free conditions

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Abstract

An effective protocol of photoredox catalyzed C2-alkylation of benzothiazoles with aliphatic carboxylic acids was disclosed. In the presence of an acridinium salt as a photocatalyst and air as an oxidant, a wide range of secondary or tertiary aliphatic carboxylic acids were employed as alkylation reagents, providing the desired products in good to excellent yields under mild reaction conditions with a broad substrate scope.

Graphical abstract: Visible-light induced decarboxylative C2-alkylation of benzothiazoles with carboxylic acids under metal-free conditions

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Publication details

The article was received on 05 Oct 2018, accepted on 30 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02476F
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Visible-light induced decarboxylative C2-alkylation of benzothiazoles with carboxylic acids under metal-free conditions

    B. Wang, P. Li, T. Miao, L. Zou and L. Wang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02476F

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