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Issue 2, 2020
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Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy

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Abstract

The past years have witnessed promising clinical feedback for anti-cancer immunotherapies, which have become one of the hot research topics; however, they are limited by poor delivery kinetics, narrow patient response profiles, and systemic side effects. To the best of our knowledge, the development of cancer is highly associated with the immune system, especially the tumor immune microenvironment (TIME). Based on the comprehensive understanding of the complexity and diversity of TIME, drug delivery strategies focused on the modulation of TIME can be of great significance for directing and improving cancer immunotherapy. This review highlights the TIME modulation in cancer immunotherapy and summarizes the versatile TIME modulation-based cancer immunotherapeutic strategies, medicative principles and accessory biotechniques for further clinical transformation. Remarkably, the recent advances of cancer immunotherapeutic drug delivery systems and future prospects of TIME modulation-based drug delivery systems for much more controlled and precise cancer immunotherapy will be emphatically discussed.

Graphical abstract: Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy

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Article information


Submitted
19 Sep 2019
Accepted
25 Nov 2019
First published
26 Nov 2019

Nanoscale, 2020,12, 413-436
Article type
Review Article

Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy

S. Han, K. Huang, Z. Gu and J. Wu, Nanoscale, 2020, 12, 413
DOI: 10.1039/C9NR08086D

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