Fabrication of H2O2-driven nanoreactors for innovative cancer treatments

Abstract

The increased production of hydrogen peroxide (H₂O₂) is a typical feature of cancerous cells. This feature is closely associated with elevated oxidative stress inside solid tumour microenvironments, which thus impairs either the growth of cancer cells or their sensitivity to many cancer therapeutics. To date, numerous innovative strategies that target tumour H₂O₂ have been designed for effective cancer treatment. More recently, with the rapid advancement of nanomedicine, several nanoreactors, which are highly efficient in converting endogenous H₂O₂ to more toxic reactive oxygen species, promoting in situ H₂O₂, or decomposing endogenous H₂O₂ to molecular oxygen for tumour hypoxia attenuation, have been designed and attempted for effective cancer treatment. This review focuses on the latest progress of such innovative H₂O₂-driven nanoreactor-mediated cancer treatments. Afterwards, future perspectives on the development of tumour H₂O₂-driven nanoreactor-mediated cancer treatments and their potential clinical translations will be discussed.