Issue 29, 2019
From the journal:

Nanoscale

Influenza mimetic protein–polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy

Chaeyeon Lee,†a   Leeja Jose,†a   KyuHwan Shim,b   Seong Soo A. An,b   Sunah Jang,c   Jae Kwang Song,c   Jun-O Jin*de  and  Hyun-jong Paik ORCID logo *a  

* Corresponding authors

a Department of Polymer Science and Engineering, Pusan National University, Busan, Republic of Korea 46241
E-mail: hpaik@pusan.ac.kr

b Department of Bionano Technology, Gachon University, Sungnam, Republic of Korea 13120

c Research Center for Bio-Based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Korea 34114

d Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, China
E-mail: jinjo@yu.ac.kr

e Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea 38541

Abstract

Stimulation of dendritic cells (DCs) by antigens (Ags) promotes an Ag-specific immune response that kills Ag-expressing pathogens. These biologically inspired nanocarriers have received much attention as tools to deliver cancer Ags to DCs. A polymer-templated protein nanoball having hemagglutinin (H1-NB) that mimics the influenza virus can be used as a cancer Ag delivery vehicle, as DCs show effective phagocytic activities against H1-NB without any adjuvant. In the present study, H1-NB containing ovalbumin (OVA), a model Ag (H1-OVA-NB), was prepared as an anti-cancer agent and evaluated for its effect on anticancer immunity. H1-OVA-NB treatments in C57BL/6 mice enhanced OVA-specific immune activation and efficiently inhibited B16-OVA tumor growth compared to control groups. Our results indicate that H1-NB is an effective carrier for Ag delivery to DCs and promotes immunotherapy to fight cancer.

Graphical abstract: Influenza mimetic protein–polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy

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Article information

DOI
https://doi.org/10.1039/C9NR03510A
Article type
Paper
Submitted
25 Apr 2019
Accepted
13 Jun 2019
First published
03 Jul 2019

Nanoscale, 2019,11, 13878-13884

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Influenza mimetic protein–polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy

C. Lee, L. Jose, K. Shim, S. S. A. An, S. Jang, J. K. Song, J. Jin and H. Paik, Nanoscale, 2019, 11, 13878 DOI: 10.1039/C9NR03510A

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