Issue 5, 2019

Viral nanoparticles can elude protein barriers: exploiting rather than imitating nature

Abstract

Protein-corona formation in body fluids and/or entrapment of nanoparticles in protein matrices (e.g. food and mucus) can hinder the delivery of nanoparticles, irrespective of the route of administration. Here we demonstrate that certain viral nanoparticles (VNPs) can evade the adhesion of a broad panel of macromolecules from several biological milieus. We also show that the permeability of VNPs through mucin gels is far superior to that of synthetic nanoparticles. The non-sticky nature of VNPs implies that they will be able to readily cross most non-specific protein and glycoprotein barriers encountered, ubiquitously, upon administration through mucosal, and non-mucosal routes.

Graphical abstract: Viral nanoparticles can elude protein barriers: exploiting rather than imitating nature

Supplementary files

Article information

Article type
Paper
Submitted
09 Nov 2018
Accepted
04 Jan 2019
First published
07 Jan 2019

Nanoscale, 2019,11, 2306-2316

Viral nanoparticles can elude protein barriers: exploiting rather than imitating nature

A. Berardi, F. Baldelli Bombelli, E. C. Thuenemann and G. P. Lomonossoff, Nanoscale, 2019, 11, 2306 DOI: 10.1039/C8NR09067J

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