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Issue 2, 2019
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[99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

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Abstract

Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems have received only limited attention so far. These studies involve the synthesis of a novel hydrophobic radio-imaging tracer consisting of a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate that can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in vivo. We provide details of the tracer synthesis, characterization of the rHDL/tracer complex, in vitro uptake, stability studies and in vivo application of this new radio-imaging approach.

Graphical abstract: [99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

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Supplementary files

Article information


Submitted
13 Sep 2018
Accepted
16 Nov 2018
First published
21 Nov 2018

Nanoscale, 2019,11, 541-551
Article type
Paper

[99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

K. Isaac-Olivé, B. E. Ocampo-García, L. Aranda-Lara, C. L. Santos-Cuevas, N. P. Jiménez-Mancilla, M. A. Luna-Gutiérrez, Luis. A. Medina, B. Nagarajan, N. Sabnis, S. Raut, L. Prokai and A. G. Lacko, Nanoscale, 2019, 11, 541
DOI: 10.1039/C8NR07484D

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