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Issue 8, 2019
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Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways

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Abstract

Covering: up to 2018

Marine and freshwater cyanobacteria produce a variety of toxic compounds that pose a threat to the health of humans, livestock and natural ecosystems world-wide. Significant research efforts have been directed towards understanding the biosynthesis of these cyanotoxins in an attempt to reduce their deleterious effects on water quality and, more recently, to harness their biotechnological potential. While a variety of complementary methods (such as bioinformatic analyses and isotope feeding studies) have been employed over the last three decades to address knowledge gaps in this field, this review focuses on the utility of heterologous expression and biochemical studies, including emerging technologies for engineering and expressing complete cyanotoxin gene clusters.

Graphical abstract: Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways

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Article information


Submitted
12 Jul 2018
First published
17 Dec 2018

Nat. Prod. Rep., 2019,36, 1117-1136
Article type
Review Article

Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways

A. Cullen, L. A. Pearson, R. Mazmouz, T. Liu, A. H. Soeriyadi, S. E. Ongley and B. A. Neilan, Nat. Prod. Rep., 2019, 36, 1117
DOI: 10.1039/C8NP00063H

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