Iridium-catalyzed α-alkynylation of cyclic nonaromatic eneformamides: application to the synthesis of azapolycyclic architectures

Abstract

A modular, regioselective, step-economical, and chelation-assisted dehydrogenative alkynylation of cyclic nonaromatic eneformamides with terminal alkynes, under iridium catalysis, is described. The versatile eneformamidynes have been skeletally remodelled to other relevant architectures, including saturated cyclic amines and azabicyclic amines.